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. 2014 Mar 11;12:16. doi: 10.1186/1478-811X-12-16

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Copyright © 2014 Jung and Robinson; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Inhibition of STAT-1 prevented the increase in phagosomal acidification during treatment with IL-12 and sIL-27R. Human macrophages were either treated with (A) DMSO as a control, (B) fludarabine, or (C) niclosamide for 6 h and then infected with BCG for an additional 48 h. Lysotracker was added at the end of infection for 1 h. (A, B, C) The images shown are representative of two independent experiments. (D) The percent association and MFI were calculated as described in the Methods section. These data are the combined results of two independent experiments ± standard error. A student’s t test was used to establish statistical significance in the 95% confidence interval between individual sample groups as indicated; *indicates that IL-12 and sIL-27R is significantly different from BCG alone (BCG). **indicates that BCG alone (BCG) is significantly different from MED alone (MED).