Table 5. P values of haplotypes for male- and female-offspring nuclear families population stratification, total association, and within-family association using QTDT. BMD values are adjusted for age, height and weight; the cutoff of significance was set at P=0.0042.

	Male-offspring families				Female-offspring families
Haplotype allele	AC	AT	CC	CT	AC	AT	CC	CT
Tests of population stratification
Lumbar spine BMD	0.255		0.911	0.315	0.991		0.181	0.398
Femoral neck BMD	0.021		0.567	0.045	0.906		0.194	0.404
Total hip BMD	0.045		0.726	0.062	0.765		0.370	0.487
Tests of total association
Lumbar spine BMD	0.679	0.250	0.611	0.361	0.840	0.017	0.754	0.954
Femoral neck BMD	0.927	0.038	0.934	0.864	0.739	0.139	0.672	0.734
Total hip BMD	0.869	0.022	0.923	0.623	0.988	0.185	0.190	0.568
Tests of within-family association
Lumbar spine BMD	0.231		0.898	0.185	0.925		0.187	0.480
Femoral neck BMD	0.046		0.628	0.066	0.789		0.180	0.372
Total hip BMD	0.070		0.782	0.063	0.804		0.150	0.374
P 1000 permutation of within-family association
Lumbar spine BMD	0.195		0.885	0.133	0.911		0.077	0.379
Femoral neck BMD	0.037		0.633	0.053	0.764		0.212	0.349
Total hip BMD	0.066		0.774	0.057	0.778		0.132	0.304