Table 1. Neoadjuvant chemotherapy used in 3 groups of osteosarcoma-bearing SD rats.
| Conventional scheduling | Metronomic scheduling | Combination scheduling | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Medicine | Concentration (mg/kg) | Frequency/week | Medicine | Concentration (mg/kg) | Frequency/week | Medicine | Concentration (mg/kg) | Frequency/week | |
| Week 0 | MTX | 1350 | 1 | MTX | 1.2 | 2 | MTX | 1350 | 1 |
| Week 1 | MTX | 1350 | 1 | MTX | 1.2 | 2 | MTX | 1350 | 1 |
| Week 2 | ADM | 10 | 1 | MTX | 1.2 | 2 | ADM | 10 | 1 |
| CDP | 20 | 1 | CDP | 20 | 1 | ||||
| Week 3 | - | MTX | 1.2 | 2 | MTX | 1.2 | 2 | ||
| Week 4 | - | MTX | 1.2 | 2 | MTX | 1.2 | 2 | ||
| Week 5 | MTX | 1350 | 1 | MTX | 1.2 | 2 | MTX | 1350 | 1 |
| Week 6 | MTX | 1350 | 1 | MTX | 1.2 | 2 | MTX | 1350 | 1 |
| Week 7 | ADM | 10 | 1 | MTX | 1.2 | 2 | ADM | 10 | 1 |
| CDP | 20 | 1 | CDP | 20 | 1 | ||||
| Week 8 | - | MTX | 1.2 | 2 | MTX | 1.2 | 2 | ||