Table 5. Results of ocular irritation test of FB-cubosomes after multiple administrations (n=6).
Group | Parameters | Eye irritation scores | |||||
---|---|---|---|---|---|---|---|
1 h | 2 h | 4 h | 24 h | 48 h | 72 h | ||
FB cubosome F1 | Corneal opacity | 0 | 0 | 0 | 0 | 0 | 0 |
Iris | 0 | 0 | 0 | 0 | 0 | 0 | |
Conjunctivae | 9 | 7 | 3 | 0 | 0 | 0 | |
Total score | 9 | 7 | 3 | 0 | 0 | 0 | |
Average | 1.5 | 1.17 | 0.5 | 0 | 0 | 0 | |
Result | Nonirritant | ||||||
FB cubosome F2 | Corneal opacity | 0 | 0 | 0 | 0 | 0 | 0 |
Iris | 0 | 0 | 0 | 0 | 0 | 0 | |
Conjunctivae | 6 | 4 | 1 | 0 | 0 | 0 | |
Total score | 6 | 4 | 1 | 0 | 0 | 0 | |
Average | 1 | 0.67 | 0.17 | 0 | 0 | 0 | |
Results | Nonirritant |