Effect of muscimol on HPPI in bicuculline treated mice. Muscimol (0.01, 0.02, or 0.1 μg) with bicuculline (0.009 μg) were injected intracisternally (IC, A) or intrathecally (IT, B). Data are expressed as means±SEMs. bP<0.05 vs the bicuculline+aCSF group. eP<0.05 vs the bicuculline+muscimol 0.01 μg group, hP<0.05 vs the bicuculline+muscimol 0.02 μg group by two-way ANOVA, Dunn's test, or the Holm-Sidak method (n=8 mice per group). kP<0.05 vs basal time point (time=0) by two way ANOVA (n=8 mice per group).