Table 2. Effects of intracisternal or intrathecal glycine, taurine, or muscimol on sedation (s).
| Intracisternal injection | |||||
|---|---|---|---|---|---|
| Group | (n=8, each) | Group | (n=8, each) | Group | (n=8, each) |
| aCSF | 62±13 | aCSF | 67±15 | aCSF | 77±14 |
| Glycine 5 μg | 42±5 | Taurine 10 μg | 49±8 | Muscimol 0.01 μg | 71±16 |
| Glycine 10 μg | 76±13 | Taurine 20 μg | 86±11 | Muscimol 0.02 μg | 89±16 |
| Glycine 25 μg | 74±14 | Taurine 40 μg | 66±11 | Muscimol 0.1 μg | 93±9 |
| Intrathecal injection | |||||
| Group | (n=8, each) | Group | (n=8, each) | Group | (n=8, each) |
| aCSF | 55±12 | aCSF | 68±14 | aCSF | 54±13 |
| Glycine 5 μg | 58±13 | Taurine 10 μg | 77±18 | Muscimol 0.01 μg | 84±17 |
| Glycine 10 μg | 73±9 | Taurine 20 μg | 82±15 | Muscimol 0.02 μg | 91±12 |
| Glycine 25 μg | 72±14 | Taurine 40 μg | 89±16 | Muscimol 0.1 μg | 104±14 |
Values are expressed as means±SEMs (n=8 mice per group). Each mouse was placed on a rubber cylinder after drug injection. Latency to step off the rubber cylinder with the hind paw was recorded. Data were analyzed using one-way ANOVA. No significant difference was observed between drug injected mice and vehicle (aCSF) controls.