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Genetic deletion of Nrf2 decreases growth of immortalized murine embryonic fibroblasts (MEFs). The figure depicts the mean values of doublings number per passage. Data from all passages between 20 and 43 were used for calculations. Wild-type (Wt) MEFs, n = 142; Nrf2−/− MEFs, n = 94. Differences between Wt and Nrf2−/− MEFs were statistically different with p < .0001.
