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Downregulation of c-Myc in HCT116 cells treated with GO-Y086 and GO-Y030. (A) HCT116 cells were treated with the compounds for 24 h and the cell lysates were analyzed by Western blotting. (B) After the HCT116 cells were treated with 3 μM of the compounds for 24 h, the relative c-myc mRNA abundance was determined by quantitative RT-PCR analysis.
