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(a) Female BALB/c mice were inoculated IP with 600 T. b. brucei (EATRO 221) parasites. Treatment with compound 12 (50 mg/kg, b.i.d.) cured 100% of mice. (b) Treatment of T. b. rhodesiense (IL1852, 104/mouse)-infected mice with compound 12 (50 mg/kg, b.i.d.) also gave parasite-free survival of the mice. Reference compound: suramin.
