Figure 2.

Antiproliferative activity of compounds 2, 7, 9, and 14 in normal bladder epithelial cell explant cultures. Explanted normal bladder epithelial cells were treated with varying concentrations of as-APF 2 (⧫), trileucine analogue 7 (●), trialanine analogue 9 (◻), or Val-Ala-Val analogue 14 (△) for 48 h prior to the determination of ³[H]-thymidine incorporation. The assay was performed in triplicate twice; data are expressed as percent inhibition of thymidine incorporation as compared to control cells incubated with medium alone.