Skip to main content
. 2010 Aug 30;1(9):510–515. doi: 10.1021/ml100178g

Scheme 2. General Synthesis Scheme.

Scheme 2

Reagents and conditions: (a) 10% aqueous NaHCO3, THF, room temperature. (b) POCl3, DMF/MeCN, room temperature. (c) NBS, DMF. (d) MeMgCl, THF, −78 °C. (e) 2 N NH3 in iPrOH, 50 °C. (f) PdCl2(dppf), K2CO3, dioxane−water (4:1, v:v), 95 °C. (g) 1-Methylpiperazine or 1-formylpiperazine, NaBH(OAc)3, THF, room temperature.