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. 2010 Aug 30;1(9):510–515. doi: 10.1021/ml100178g

Table 1. In Vitro Potency and Microsomal Stability of Compounds 1a and 1b.

        extraction ratios
compound X IGF-1R biochemicala IC50 (μM) IGF-1R cell mechanisticb IC50 (μM) mouse human
1a N 0.27 0.33 0.89 0.91
1b CH 0.079 0.086 0.88 0.85
a

A 100 μM concentration of ATP.

b

LISN cell line.