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. 2010 Aug 30;1(9):510–515. doi: 10.1021/ml100178g

Table 2. Further SAR Explorations.

					extraction ratios
	R¹	R²	IGF-1R cell mechanistic^a IC₅₀ (μM)	IR cell mechanistic^b IC₅₀ (μM)	mouse	human
9a	H		0.15	0.70	0.62	0.71
9b	F		0.017	0.076	0.43	0.55
11a	H	CHO	0.026	0.26	0.24	0.66
11b	F	CHO	0.008	0.048	0.44	0.65
11c	H	CH₃	0.025	0.32	0.52	0.64
11d	F	CH₃	0.014	0.068	0.44	0.50

^a

LISN cell line.

^b

HepG2 cell line.