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. 2010 Aug 30;1(9):510–515. doi: 10.1021/ml100178g

Table 3. PAMPA Permeability and Mouse PKa of 9b, 11b, and 11d.

  PAMPA (nm/s)
 5 mg/kg iv dose
 25 mg/kg po dose
  pH 5.0 pH 7.4 Cl (mL/min/kg) Vss (L/kg) Cmax(μM) F %
9b 1090 1100 4 1.0 20.5 162
11b 204 1050 7 1.2 3.1 18
11d 145 672 21 4.9 1.9 27
a

Compounds were dosed as freebase in female CD-1 mice.