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| species | dose (mg/kg) | Cmax (μM) | AUC (ng h/mL) | CL (mL/min/kg)c | Vss (L/kg)c | F % |
|---|---|---|---|---|---|---|
| rat (F) | 25a | 11.3 | 62415 | 4 | 0.97 | 64 |
| rhesus monkey (M) | 30b | 10.8 | 31383 | 15 | 0.55 | 97 |
| mouse (F) | 25b | 35.2 | 240013 | 4 | 1.00 | 100 |
Free base of 9b was dosed; vehicle, 50:50 PEG-400:25 mM tartaric acid.
HCl salt of 9b was dosed; vehicle, 40% w/v hydroxypropyl-β-cyclodextrin (Trappsol).
A 5 mg/kg iv dose.
