Figure 2.
GSTA2 S112T locus impacts serum bilirubin and plasma busulfan levels. (A) Busulfan AUC in patients receiving busulfan according to GSTA2 S112T genotypes (ser/ser, n=8, thr+, n=56); P values refer to multivariate GLM adjusted for age, gender, BMI and source of HSC. (B) Bilirubin serum levels according to GSTA2 S112T genotypes (ser/ser, n=20, thr+, n=99) from pre-transplant to 35 days post-transplant; P value is referred to GLM Anova for repeated measures, adjusted for age, sex mismatch, interval from diagnosis to transplant, intensity of conditioning and disease phase at transplant.