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. 2010 Jul 2;1(7):336–339. doi: 10.1021/ml100097f

Table 1. In Vitro Anticancer Potency, Tumor Selectivity, and COMPARE Analysis Results for the Described Gold(III) Compounds.

compound mean IC50 (μg/mL) mean IC70 (μg/mL) tumor selectivity ratinga proposed target by COMPARE analysis
1-(PF6)2 0.036 0.245 +++ HDAC
Auoxo6 0.572 4.438 +++ HDAC
Auphen 0.370 1.019 + CDK
a

Selective activity (individual IC70 < 1/3 of mean IC70 value) in + (4−10% of cell lines), ++ (10−20% of cell lines), and +++ (more than 20% of cell lines).