Figure 2.

 Learning from recent megatrials. The key components of a clinical trial include baseline assessments and delivery of protocol by a team with frequent monitoring and documentation of processes and responses. This team‐based approach enables risk stratification, informed decisions, individualized regimens, regular monitoring, improved compliance and better outcomes. In order to increase the accessibility of these care models, changes in clinical practice and health care system is needed to ensure its accessibility, affordability and sustainability.