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Schematic diagram of the pancreatic β‐cell showing the proposed subcellular localization of proteins encoded by diabetes‐associated genes. HNF4a, HNF1α, HNF1β and TCF7L2 encode transcription factors produced in the β‐cell and are implicated in pancreatic development. WFS1 encodes wolframin, a protein that regulates calcium transport in the endoplasmic reticulum. CDKAL1 and CDKN2A/B are involved in the cyclin‐dependent kinase pathway, and might thus influence β‐cell regeneration.
