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. 2014 May;99(5):836–847. doi: 10.3324/haematol.2013.087536

Figure 1.

Figure 1.

NK surface phenotype is abnormal in AML compared to healthy controls. NK receptor surface expression in 32 patients with AML at diagnosis compared with 15 healthy controls. (A) Gating strategy for AML-NK surface phenotype results. AML-NK were gated on CD13, CD33 and/or CD34−, CD3, CD56+ lymphocyte fraction of PBMCs. (B) Histograms showing NK surface phenotype in a representative AML patient and healthy control. Open histograms represent isotype matched monoclonal antibody staining. Filled histograms represent staining with specific PE-conjugated monoclonal antibodies. NK surface receptor phenotype of (C) C-type lectins (D) NCRs (E) KIR (F) CD56 bright and dim. Horizontal bars denote mean expression. Error bars denote standard deviation between individuals within group. KIR: killer immunoglubulin receptor; NCR: natural cytotoxicity receptor; HC: healthy control; AML: acute myeloid leukemia.