Table 4.

Combined chronic C. pneumoniae and recurrent A. actinomycetemcomitans infections-enriched GO terms in the inguinal AT transcriptome

GO category	Enriched GO term	GO term p-value a	GO term-associated gene products
			Up-regulated b	Down-regulated b
GO:0005515	Protein binding	<0.001	Igk-V5, Igkv5-48, Igkv4-80, Igkv8-30, IgkV33, Igkv12-89, Igkv15-103, Igkv2-112, D6Mit97, S100a8, Ltf, LOC637260, LOC626347, Igl, Ighv1-62, Ighv6-3, LOC630305, Ighg3, Igh-4,Ighg, LOC100047788, Gm16971, Ngp, Chi3l3	Aldh1a1, Adh7, Ddx17, Acta1, Bmp3, Igfbp6, Tnnc2, Lep, Dpt
GO:0003823	Antigen binding	<0.001	LOC100047788, Igkv5-48, Igkv2-112	-
GO:0019731	Antibacterial humoral response	0.002	LOC100047788	-
GO:0019730	Antimicrobial humoral response	0.002	LOC100047788	-
GO:0051952	Regulation of amine transport	0.002	-	Lep, Sncg
GO:0042572	Retinol metabolic process	0.011	-	Aldh1a1, Adh7
GO:0030534	Adult behavior	0.011	-	Lep, Sncg
GO:0014059	Regulation of dopamine secretion	0.011	-	Sncg
GO:0014046	Dopamine secretion	0.011	-	Sncg
GO:0006836	Neurotransmitter transport	0.011	-	Slc6a13, Sncg
GO:0042573	Retinoic acid metabolic process	0.013	-	Aldh1a1, Adh7
GO:0002455	Humoral immune response mediated by circulating immunoglobulin	0.016	LOC100047788	-
GO:0046928	Regulation of neurotransmitter secretion	0.020	-	Sncg
GO:0008344	Adult locomotory behavior	0.042	-	Sncg
GO:0032526	Response to retinoic acid	0.044	-	Aldh1a1, Lep
GO:2000366	Positive regulation of STAT protein import into nucleus	0.046	-	Lep
GO:0071298	Cellular response to L-ascorbic acid	0.046	-	Lep
GO:0060587	Regulation of lipoprotein lipid oxidation	0.046	-	Lep
GO:0051956	Negative regulation of amino acid transport	0.046	-	Lep
GO:0034439	Lipoprotein lipid oxidation	0.046	-	Lep

^aP-values are corrected for multiple hypotheses using Benjamini-Hochberg false discovery rate.

^bFold change limit 2.0.

Number of biological replicates is 3.

GO, gene ontology. The maximum of 20 GO categories is shown.