Table 8.
Relative changes in mRNA expression levels of selected genes in inguinal and epididymal AT
| |
Aa group |
Cpn group |
Cpn + Aa group |
|
|---|---|---|---|---|
|
(n = 10) |
(n = 10) |
(n = 10) |
||
| Tissue | Gene |
Median Log
2
fold change (IQRs)
a
|
||
| p-value b | ||||
|
Inguinal AT |
Mcp-1
|
-0.78 (1.96) |
-0.31 (1.44) |
-0.53 (1.76) |
| 0.671 |
0.348 |
0.020 |
||
|
Mrc-1
|
-0.19 (1.05) |
-0.17 (1.00) |
0.02 (2.08) |
|
| 0.671 |
1.000 |
1.000 |
||
|
CD68
|
0.44 (1.56) |
0.25 (1.23) |
0.03 (1.36) |
|
| 0.203 |
0.061 |
0.437 |
||
|
Mif
|
0.57 (2.15) |
0.40 (1.94) |
-0.11 (1.67) |
|
| 0.203 |
0.348 |
1.000 |
||
|
Slpi
|
4.73 (2.99) |
-1.18 (3.55) |
2.79 (6.50) |
|
| 0.003 |
0.061 |
0.437 |
||
|
Mpo
|
4.30 (2.64) |
-0.48 (3.75) |
4.04 (7.01) |
|
| 0.009 |
0.115 |
0.348 |
||
|
Epididymal AT |
Mcp-1
|
-0.73 (1.97) |
-0.41 (1.88) |
-1.03 (1.46) |
| |
|
0.020 |
0.203 |
<0.001 |
| |
Mrc-1
|
-0.16 (0.88) |
0.60 (0.53) |
-0.17 (0.99) |
| |
|
0.437 |
0.003 |
0.599 |
| |
CD68
|
-0.39 (0.90) |
0.58 (0.76) |
0.55 (1.86) |
| |
|
0.120 |
0.034 |
0.600 |
| |
Mif
|
-0.88 (0.70) |
-0.13 (1.06) |
-0.86 (0.67) |
| |
|
0.020 |
0.203 |
<0.001 |
| |
Slpi
|
-0.89 (2.11) |
0.20 (2.20) |
-0.24 (2.07) |
| 0.002 | 0.203 | 0.600 | ||
aMedian Log2 fold change (IQRs) to the control mice. The control mice have been set into the value of 0.
bThe Mann–Whitney U Test with the control mice as the reference group.
Aa group, recurrent A. actinomycetemcomitans infection; Cpn group, chronic C. pneumoniae infection; Cpn + Aa group, combined recurrent A. actinomycetemcomitans and chronic C. pneumoniae infections; IQR, interquartile range; Mcp-1, monocyte chemoattractant protein 1; Mif, macrophage migration inhibitory factor, Mrc-1, mannose receptor C type 1; Mpo, myeloperoxidase; Slpi, secretory leukocyte peptidase inhibitor.