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. Author manuscript; available in PMC: 2014 May 2.
Published in final edited form as: Cell Rep. 2013 Aug 29;4(5):870–878. doi: 10.1016/j.celrep.2013.07.041

Figure 4. Human SVs permit aNHEJ and impair genomic stability.

Figure 4

(A) Structurally predictive software to measure the inherent disorder and flexibility of the acidic hinge was used to compare the identified human RAG2 mutations with the wild-type sequence. (B) Human RAG2 acidic region SVs were tested for their ability to permit aNHEJ. (C) Metaphases from cells expressing the indicated RAG2 mutants with the Igk locus on chromosome 6 indicated. (D) Quantification of aberrant metaphases observed in C. Results from separate experiments (Figure S4) were collected and combined. Statistical analysis was conducted using a one-tailed Fisher’s exact test for comparison to the wild-type complemented aberrant metaphases. Error bars reflect the standard error of the mean.