Fig. 1. Nlrp3 knock-ins show growth impairment.

Nlrp3 CreZ knock-in pups - with the aspartate 301 to asparagine (D301N) substitution (A) – were often indistinguishable from wild type (WT) siblings at birth but showed growth retardation with significantly lower body weight after 2 weeks (B,C). Notably, Nlrp3 mutants showed significant higher liver weight as a percentage of body weight than WTs; Nlrp3 CreZ median 6.3%, WT 3.5% (D); (n≥7 for each group).