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. 2014 Apr 24;142(2):227–236. doi: 10.1111/imm.12245

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© 2014 The Authors. Immunology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Highly oligoclonal CD8⁺ T-cell receptor β variable region (TCRVb) repertoire early in immune reconstitution in patients, who were in remission after autologous stem cell transplantation (ASCT), (Patterns A and B) compared with high TCRVb diversity in the patient who relapsed (Pattern C). Patient 1 (a) and patient 2 (b) TCRVb CDR3 length spectratyping for respective TCRVb falling into pattern A (left) and pattern B (right); TCRVb as labelled; samples tested for patient 1: before and 1 and 12 months after ASCT and for patient 2: before and 23·5 months after ASCT. (c) TCRVb CDR3 length spectratyping in same Vb families before and 3 months after ASCT in patient 3 (pattern C).