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Average concentration × time curves for each dose level (mg/m2/dose). Plasma samples were obtained on cycle 1, day 1 for patients receiving once-daily dosing (45, 60, 80, and 100 mg/m2/dose) and twice-daily dosing (30 or 40 mg/m2/dose, twice daily). For patients receiving twice-daily dosing the second dose of MLN8237 on day 1 was not administered for accurate determination of pharmacokinetic parameters.
