Table 4.

Neurologic toxicity regardless of attribution while on MLN8237

Part and schedule	Dose level (mg/m2/dose)	Pt. no.	Description and grade
A1 (daily)	45	4	Somnolence, Gr 2
		5	Anxiety, Gr 1; depression, Gr 1; somnolence, Gr 2
		6	Depression, Gr 2
		7	Agitation, Gr 1
	60	13	Somnolence, Gr 2; memory impairment, Gr 2
	80	15	Euphoria, Gr 2
		16	Depression, Gr 4a
		17	Agitation; Gr 2
		19	Depression, Gr 1
	100	20	Agitation, Gr 1
		21	Somnolence, Gr 2; dizziness, Gr 1
		23	Agitation, Gr 1
		24	Dizziness, Gr 1
A2 (twice daily)	40	27	Personality/behavioral, Gr 1
		29	Somnolence, Gr 2
		31	Depression, Gr 1; dysphoria, Gr 1
	30	32	Agitation, Gr 1
		36	Personality/behavioral, Gr 1

^aGrade 1 depression at baseline.