Table 3.
Baseline immunological characteristics of 5 clusters of 79 PHID patients, ALTADIH Cohort, 2007-2010
|
Cluster 1 |
Cluster 2 |
Cluster 3 |
Cluster 4 |
Cluster 5 |
||
|---|---|---|---|---|---|---|
| n = 33 | n = 18 | n = 4 | n = 8 | n = 16 | ||
| IgG |
g/L |
4.37 (3.80, 5.32) |
5.73 (4.7, 6.3) |
4.68 (2.69, 5.29) |
1.44 (0.30, 2.71) |
3.69 (1.65, 4.22) |
| IgA |
g/L |
0.63 (0.14, 1.62) |
1.02 (0.07, 1.55) |
0.60 (0.04, 2.09) |
0.15 (0.01, 0.43) |
0.19 (0.05, 0.79) |
| IgM |
g/L |
0.55 (0.31, 1.09) |
0.48 (0.24, 0.78) |
0.54 (0.34, 0.62) |
0.16 (0.05, 0.42) |
0.27 (0.20, 0.47) |
|
B cells |
|
|
|
|
|
|
| CD19+ |
cells/mm3 |
157 (128, 244) |
128 (102, 211) |
49 (20, 87) |
122 (94, 176) |
51 (29, 119) |
| CD27-IgD+ |
% CD19+ |
68.85 (52.03, 74.47) |
68.89 (57.94, 77.24) |
49.52 (10.73, 80.43) |
90.89 (82.94, 93.31) |
84.03 (70.93, 90.82) |
| CD27-IgD- |
% CD19+ |
2.80 (2.18, 4.38) |
3.90 (2.24, 6.42) |
6.13 (2.64, 23.40) |
2.40 (1.67, 2.58) |
2.65 (1.72, 4.22) |
| CD27 + IgD+ |
% CD19+ |
15.01 (10.11, 23.19) |
10.53 (4.42, 13.73) |
5.67 (2.43, 8.57) |
3.57 (2.21, 7.20) |
4.92 (1.32, 7.92) |
| CD27 + IgD- |
% CD19+ |
14.39 (7.08, 20.05) |
13.93 (7.26, 24.33) |
7.77 (2.43, 19.38) |
2.55 (0.94, 3.91) |
2.97 (0.36, 6.66) |
|
T cells |
|
|
|
|
|
|
| CD3+ |
cells/mm3 |
1363 (1076, 1787) |
1045 (883, 1456) |
2756 (1472, 4183) |
831 (658, 1075) |
579 (407, 837) |
| CD4+ |
cells/mm3 |
835 (571, 1214) |
789 (573, 967) |
848 (609, 1227) |
382 (302, 565) |
308 (244, 565) |
| CD8+ |
cells/mm3 |
477 (358, 604) |
270 (159, 383) |
1621 (710, 2682) |
293 (196, 362) |
213 (141, 266) |
| CD4+/CD8+ ratio |
|
1.89 (1.45, 2.42) |
2.77 (2.31, 4.08) |
0.60 (0.42, 1.06) |
1.26 (0.67, 2.65) |
1.89 (1.17, 2.61) |
|
CD8+ T cells
|
|
|
|
|
|
|
| CD45RA + CCR7+ |
% CD8+ |
19.05 (11.11, 34.59) |
28.47 (13.32, 43.67) |
1.52 (0.56, 2.75) |
4.91 (1.53, 53.19) |
35.56 (10.29, 53.19) |
| CD45RA-CCR7+ |
% CD8+ |
0.83 (0.46, 1.90) |
4.60 (1.96, 7.97) |
0.53 (0.21, 0.82) |
0.82 (0.30, 1.20) |
1.37 (0.85, 1.96) |
| CD45RA-CCR7- |
% CD8+ |
31.28 (24.26, 36.96) |
43.13 (32.60, 57.14) |
36.82 (16.56, 57.25) |
39.24 (30.69, 59.20) |
29.14 (17.47, 42.55) |
| CD45RA + CCR7- |
% CD8+ |
41.48 (32.61, 52.32) |
22.30 (16.87, 27.10) |
40.75 (13.96, 59.90) |
48.28 (30.47, 63.41) |
29.25 (18.76, 39.37) |
| CD8 + CD57+ |
% CD8+ |
17.52 (9.42, 30.97) |
7.38 (4.41, 15.97) |
27.36 (19.36, 47.30) |
39.61 (33.78, 51.16) |
13.51 (8.35, 23.44) |
|
Activated T cells
|
|
|
|
|
|
|
| CD3 + HLA-DR+ |
% CD3+ |
12.04 (7.62, 16.95) |
9.87 (7.11, 12.83) |
52.00 (32.71, 59.56) |
46.56 (40.76, 57.25) |
13.65 (6.19, 20.33) |
| CD4 + HLA-DR+ |
% CD4+ |
5.88 (4.94, 9.17) |
6.75 (4.95, 9.13) |
48.30 (26.32, 56.25) |
43.87 (30.88, 49.95) |
11.54 (6.52, 18.33) |
| CD8 + HLA-DR+ |
% CD8+ |
25.48 (14.86, 31.93) |
19.73 (14.18, 26.44) |
53.48 (37.05, 65.52) |
62.14 (47.01, 76.39) |
15.12 (10.65, 28.64) |
|
Regulatory T cells |
cells/mm3 |
54 (33, 76) |
41 (24, 82) |
18 (13, 22) |
19 (12, 24) |
15 (8, 18) |
|
NK cells |
cells/mm3 |
143 (100, 214) |
174 (121, 230) |
268 (146, 388) |
75 (55, 103) |
41 (26, 70) |
|
Dendritic cells |
|
|
|
|
|
|
| Myeloid |
/ml |
11940 (8751, 17805) |
11422 (6616, 13457) |
9122 (5662, 29989) |
7795 (4086, 10548) |
5420 (4107, 9683) |
| Plasmacytoid |
/ml |
7217 (4801, 11084) |
6152 (3599, 9836) |
2771 (1766, 8490) |
3073 (1351, 3618) |
2766 (2194, 4255) |
|
Gammadelta cells |
cells/mm3 |
44 (20, 74) |
27 (11, 54) |
396 (178, 579) |
19 (6, 92) |
16 (9, 26) |
| Gammadelta 2 | % GD | 62.96 (40.85, 73.68) | 78.71 (75.00, 89.39) | 13.40 (8.77, 30.62) | 6.59 (4.09, 25.61) | 25.00 (12.41, 55.96) |
Results are expressed as medians (interquartile range values).