Table 2.

Parameter estimates from AMD population pharmacokinetic models

	Historical model	Base model	Contamination model
Parameter (Point estimate, % RSE)
CL, L/h/70 kg	9.99 (11.2)	9.82 (12.2)	11 (9.36)
V1, L/70 kg	3.56 (39.3)	3.17 (61.8)	5.79 (18.3)
V2, L/70 kg	16.1 (80.7)	16.1 (116)	24.2 (69.4)
V3, L/70 kg	367 (19.7)	367 (28.1)	490 (8.29)
Q2, L/h/70 kg	11.4 (58.8)	10.9 (93.6)	17.7 (38)
Q3, L/h/70 kg	25.2 (23.3)	24.1 (35.1)	42.8 (13.6)
CL, Q2, Q3 ~ WT/70 power	3/4 fixed	3/4 fixed	3/4 fixed
V1, V2, V3 ~ WT/70 power	1 fixed	1 fixed	1 fixed
V1 ~ AGE/8.8 power	-	-0.329 (30.4)	-0.448 (26.6)
CTM	-	-	0.193 (17.9)
Ke, h−1	-	-	0.0932 (18.1)
IIV (% CV, % RSE)
${\omega }_{\mathrm{CL}}^2$	40.4 (56.3)	39.9 (60.8)	48.4 (28.1)
${\omega }_{\mathrm{V}1}^2$	49 (36.2)	41.6 (54.5)	24.6 (64.2)
${\omega }_{\mathrm{CTM}}^2$	-	-	127 (40.9)
COVCL,VI	-0.057a	-0.0412a	-0.0507a
COVCL,CTM	-	-	-0.198a
COVV1,CTM	-	-	-0.0601a
Residual variance (% CV, % RSE)
${\sigma }_{\text{prop}}^2$	24.7 (34.5)	24.6 (33.2)	19.6 (27)

IIV inter-individual variability, CL clearance, COV_CL,Vl covariance between random effect of CL and V, CTM contamination factor, CV coefficient of variation, Ke rate constant for change in contamination factor, Q2 and Q3 inter-compartmental clearance, RSE relative standard error of the estimate, VI volume of central compartment, V2 and V3 volume of peripheral compartment; WT body weight, ${\omega }_{\mathrm{CL}}^2$ and ${\omega }_{\mathrm{V}1}^2$ variances of random effect of CL and V1, respectively, ${\sigma }_{prop}^2$ proportional residual error model

^aPoint estimate