Table 3.
Simulated patient demographics and simulated concentrations of the prospective trial
| Age group (years) | n | Demographics |
Simulated concentrations (ng/mL) |
|||
|---|---|---|---|---|---|---|
| Variable | Mean (range) | Time (min) | PIV, mean (95 % CI) | CVL, mean (95 % CI) | ||
| <1 | 35 | Age (years) | 0.46 (0.01-0.88) | 5 | 43 (9.0-77) | 62 (11-170) |
| Weight (kg) | 7.13 (2.77-11.4) | 10 | 24 (7.1-39) | 34 (8.8-92) | ||
| Dose (mg) | 0.17 (0.06-0.28) | 60 | 4.5 (2.5-7.3) | 6.4 (2.8-16) | ||
| 1 ≤ Age < 3 | 35 | Age (years) | 2.01 (1.13-2.96) | 5 | 113 (58-168) | 162 (68-409) |
| Weight (kg) | 12.2 (8.18-17.1) | 10 | 53 (16-86) | 76 (20-195) | ||
| Dose (mg) | 0.52 (0.37-0.77) | 60 | 7.6 (4.4-12) | 11 (4.9-27) | ||
| 3 ≤ Age < 12 | 35 | Age (years) | 7.43 (3.21-11.2) | 5 | 131 (48-204) | 188 (62-477) |
| Weight (kg) | 24.8 (14.5-53.8) | 10 | 49 (11-95) | 69 (13-182) | ||
| Dose (mg) | 1.06 (0.65-2.42) | 60 | 7.7 (4.5-11) | 11 (5.0-27) | ||
| 12 ≤ Age < 17 | 35 | Age (years) | 14.2 (12.0-17.0) | 5 | 140 (44-225) | 200 (54-515) |
| Weight (kg) | 56.0 (30.3-86.2) | 10 | 47 (8.8-102) | 67 (10-191) | ||
| Dose (mg) | 2.48 (1.36-2.5) | 60 | 7.4 (4.2-11) | 10 (4.6-26) | ||