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. 2014 Mar 10;10:17. doi: 10.1186/1744-8069-10-17

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Copyright © 2014 Kurihara et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effects of CK1 inhibitors on carrageenan-induced acute inflammatory pain behaviors. (A, B) Effects of intrathecal injection of IC261 on carrageenan (Car)-induced thermal hyperalgesia. IC261 was injected 5 hour after (A) or 30 min before (B) carrageenan injection. (C, D) Effects of intrathecal injection of TG003 on carrageenan (Car)-induced mechanical allodynia (C) and thermal hyperalgesia (D). Paw withdrawal threshold to mechanical stimulation and paw withdrawal latency to thermal stimuli are plotted against the time after carrageenan injection into a hindpaw. Data are mean ± SEM. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, compared with pre-drug data (one-way ANOVA followed by Dunnett’s post hoc test).