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. 2014 Mar 10;10:17. doi: 10.1186/1744-8069-10-17

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Copyright © 2014 Kurihara et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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IC261 decreased the mean frequency and amplitude of sEPSCs in inflammatory pain model mice. Representative traces of sEPSCs in SG neurons of the spinal cord slices from naïve control (A), carrageenan (B)- and CFA (C)-inflamed mice showing the effects of IC261 (1 μM). Lower five traces represent sEPSCs at five given points in time presented above the upper trace, and are shown in an expanded time scale. (D) Summary of results, testing the effects of IC261 on the sEPSC frequencies and amplitudes The percentage compared to pre-drug response (as 100%) was shown as% control. ^*P < 0.05, ^**P < 0.01, compared with pretreatment control (Student’s t test).