Figure 5. Heatmap and hierarchical clustering of select secondary metabolite peak volumes in LCMS runs on L. patella extracts (top left).

Clustering based on secondary metabolites that are produced by the symbiotic bacteria Prochloron didemni and Ca. Endolissoclinum faulkneri closely follows the hosts' phylogeny as determined by COXI sequences (see Fig. 2). The P. didemni compounds shown are all cyanobactins produced either by a patellamide-type pathway (red), or a trunkamide-type pathway (blue). These two types of are closely related ribosomal pathways that are highly tolerant to changes in the precursor peptide sequence. The patellazoles (magenta) are produced by another symbiont, Candidatus Endolissoclinum faulkneri, by a polyketide synthase pathway.