Figure 1. A schematic presentation of the key differences between tissue-extracted vs. plant-derived human collagen. Plant-derived human collagen Type I (rhCOL1) exhibits a natural α-helical structure, with natural cell binding domains, while tissue-extracted collagen is stripped of many of its clinically relevant binding domains, alongside introduction of unwarranted crosslinks, which impact the protein structure and function. Plant-derived human collagen forms functional 3D matrices, surpassing the capacities of their tissue-extracted counterparts. rhCOL1 provides an optimal medium for cell proliferation and accelerated wound healing, with no concerns of antigenicity and immunogenicity.