Table 1. Key physical and biological features of rhCOL1.

Feature	Advantage	Benefit
Human amino acid sequence	• Non-immunogenic	• Improved biocompatibility
Triple helix structure	• Increased stability • Densely packed fibers • D-band striation • Improved cell adhesion and cell proliferation	• Accelerated healing • Improved scaffold mechanical properties
Non-crosslinked collagen molecules	• Higher solubility • Higher fiber organization • Controllable degree of crosslinking • Controlled biodegradation	• Optimal healing processes • Simplicity of processing (electrospinning) • Improved scaffold mechanical properties • Control of new tissue growth • Improved safety • Improved cell proliferation and adhesion •
Homogeneity, liquid crystal formation	• Manipulable physical properties (e.g., compression/tensile strength; modulus of elasticity)	• Scaffold optimization for various indications • Product consistency
Plant-derived material	• Free of foreign animal tissue contaminants • Virgin non-recycled material • Consistent raw material properties	• Improved safety • Product consistency
Hydrophilicity	• Higher solubility • Higher liquid retention • Increased cell binding • Increased growth factor binding	• Ideal delivery vehicle for growth factors • Enables dose reduction of growth factors • Scaffold reproducibility • Increased safety