Figure 7. Effect of PF-3845 treatment on below-level cutaneous hypersensitivity in rats with neuropathic SCI pain.

Following baseline hind paw withdrawal threshold measurement, SCI rats were treated with either PF-3845 (3, 10 mg/kg, p.o.) or vehicle (Veh; 5 ml/kg, p.o.). An antinociceptive effect was observed 1 and 3 hours following administration of 10 mg/kg, but not 3 mg/kg. Data presented as mean ± S.E.M. n = 8–9/group. * p<0.05 vs. vehicle (Two-way repeated measures ANOVA, Student-Newman-Keuls test).