Table 3. Fold-change of tissue fatty acid amide levels following a single oral treatment with PF-3845 compared to oral vehicle treatment.
| AEA | OEA | PEA | ||||||||||||||
| Rats | Treatment | Brain | Rostral | Epicenter | Caudal | Lumbar | Brain | Rostral | Epicenter | Caudal | Lumbar | Brain | Rostral | Epicenter | Caudal | Lumbar |
| SCI | Vehicle | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| SCI | PF, 3 | 2.9 (**) | 9.8 (***) | 4.3 (***) | 5.7 (***) | 4.6 (***) | 5.2 (***) | 4.1 (***) | 2.7 (**) | 3.4 (***) | 3.3 (***) | 4.5 (***) | 3.3 (***) | 2.0 (**) | 2.6 (***) | 2.8 (***) |
| SCI | PF, 10 | 3.2 (**) | 7.7 (***) | 5.9 (***) | 6.2 (***) | 4.7 (***) | 4.9 (***) | 3.3 (***) | 3.9 (***) | 3.8 (***) | 3.8 (***) | 4.2 (***) | 2.6 (***) | 2.8 (***) | 2.8 (***) | 3.1 (***) |
| N.I. | Vehicle | 1 | — | 1 | — | 1 | 1 | — | 1 | — | 1 | 1 | — | 1 | — | 1 |
| N.I. | PF, 3 | 6.4 (***) | — | 5.6 (***) | — | 5.5 (***) | 10.2 (***) | — | 3.6 (***) | — | 3.7 (***) | 10.4 (***) | — | 2.6 (***) | — | 3.1 (***) |
| N.I. | PF, 10 | 5.8 (***) | — | 6.0 (***) | — | 5.8 (***) | 8.9 (***) | — | 4.9 (***) | — | 3.8 (***) | 10.1 (***) | — | 3.4 (***) | — | 3.5 (***) |
Values are fold-changes compared to vehicle treatment levels in spinal cord injured (SCI) and non-injured (N.I) rats. Tissues were collected 4 hours post-oral administration of either PF-3845 (3, 10 mg/kg) or vehicle.
“Epicenter” refers to thoracic spinal cord tissue either from the site of injury from SCI rats or comparable spinal cord tissue from non-injured rats.
*p<0.05, **p<0.01, ***p<0.001 vs. vehicle-treated (Student's t-test).