Table 1. Proportion of population and 95%CIs for each category of risk considering only HLA-DRB1, HLA-DRB1 + MS associations known in 2011 and HLA-DRB1 + all currently known MS associations.

Model considered		Risk Category
		Reduced	Average	Elevated	High
HLA-DRB1	95% CI	0–0.89	0.89–1.12	1.12–3.27	3.27–Inf
	Proportion of population	0.0%	63.8%	32.1%	4.1%
HLA-DRB1 + Old associations	95% CI	0–0.76	0.76–1.34	1.34–2.06	2.06–Inf
	Proportion of population	44.8%	41.6%	7.5%	6.1%
HLA-DRB1 + All associations	95% CI	0–0.70	0.70–1.47	1.47–2.71	2.71–Inf
	Proportion of population	40.8%	49.0%	6.9%	3.3%

In brief, GWAS statistics (OR and risk allele frequencies) are used to simulate a population of 100,000 individuals. An overall genetic risk of MS is calculated for each individual and scaled by the mean risk profile. Categories of risk are defined based on the 95%CI of risk of each individual (see methods).