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. 2014 May 2;9(5):e96327. doi: 10.1371/journal.pone.0096327

Figure 3. Relations between levels of BBB-opening and acoustic-emission signals under 10-MHz sonication.

Figure 3

A: EB extravasation into brain tissue. (white arrows: the BBB-opening region; red arrows: areas of erythrocyte extravasations). B: Acoustic-emission change ratio (red line: in-house submicron bubbles with 10-MHz FUS sonication; blue line: SonoVue with 10-MHz FUS sonication; solid line: subharmonic-frequency signal; dotted line: ICD. C: Correlation between acoustic-emission signals and amount of EB extravasation for in-house submicron bubbles with 10-MHz FUS sonication.