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. 2014 May 2;9(5):e96327. doi: 10.1371/journal.pone.0096327

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© 2014 Fan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: In-house submicron bubbles with 10-MHz FUS sonication. B: SonoVue with 10-MHz FUS sonication. C: In-house submicron bubbles with 1-MHz FUS sonication. D: SonoVue with 1-MHz FUS sonication. (white arrows: the BBB-opening region; red arrows: areas of erythrocyte extravasations; blue arrows: brain edema).