Table 1. Sonication parameters of the four experimental groups.

	Group 1	Group 2	Group 3	Group 4
Number of rats	34	34	30	30
Acoustic pressure (MPa)	0.5–4.5	0.5–4.5	0.1–1.5	0.1–1.5
Pulse repetition frequency (Hz)	10	10	10	10
Number of cycles	10000	10000	10000	10000
Duration of sonication (s)	60	60	60	60
Number of MRI evaluations	18	18	18	18
Number of H&E staining evaluations	18	18	18	18
Number of TUNEL staining evaluations	18	18	18	18
Number of EB staining evaluations	34	34	30	30

Group 1  =  in-house submicron bubbles with 10-MHz FUS sonication; Group 2  =  SonoVue with 10-MHz FUS sonication; Group 3  =  in-house submicron bubbles with 1-MHz FUS sonication; Group 4  =  SonoVue with 1-MHz FUS sonication.