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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Obesity (Silver Spring). 2014 Jan 9;22(5):1287–1295. doi: 10.1002/oby.20678

Figure 4.

Figure 4

Fat Mass (A, B) and lean mass (C, D) in mice maintained on HFD ad lib throughout the study (A, C) or weight reduced by 20% prior to drug administration (B, D) measured prior to and 12 weeks after MC4R agonist treatment. Formerly WR mice given high nominal drug dose (53.4 nmol/day) achieved a significantly lower body fat than the controls after an 8 week body weight regain period.

Nominal doses of AZD2820 - High : 53.4 nmol/day; Medium : 10.8 nmol/day; Low : 2.64 nmol/day. Each data point represents mean fat mass or lean (fat free mass) for each group with SEM. *P < 0.05 between vehicle and high dose treated groups by Student’s t-test.