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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Obesity (Silver Spring). 2014 Jan 9;22(5):1287–1295. doi: 10.1002/oby.20678

Figure 8.

Figure 8

Absolute total (A) and resting (B) energy expenditure (kcal/24h) measured at 12–13 weeks of drug treatment and immediately prior to sacrifice by indirect calorimetry (TSE LabMaster system). No significant difference was found in absolute total and resting EE among treatment groups. Body Composition in AL mice (C) and formerly WR mice (D) at 12 weeks of drug treatment. Formerly WR mice treated with high dose of MC4R agonist have a significantly lower BW and fat mass but show the same TEE and REE. (E) Resting energy expenditure (kcal/24h) per unit of lean mass (g) measured at 12–13 weeks of drug treatment and immediately prior to sacrifice by indirect calorimetry (TSE LabMaster system). Nominal doses of AZD2820 - High : 53.4 nmol/day; Medium : 10.8 nmol/day; Low : 2.64 nmol/day. *P < 0.05 between vehicle and high dose treated groups by Student’s t-test.