Table.

Ethical Principles in IBD Research

Ethical Standard	Specific Considerations in IBD-Related Human Subject Research
Beneficence	— Dissemination of experimental findings — Subjects’ access to the study drug following conclusion
Non—maleficence	— Nonuse of a placebo-only arm — Patient protection accompanying use of biologic agents
Respect for Persons	— Informed consent for any protocol with unknown expectations — Full disclosure of surgical innovation and informed consent prior to new procedures
Justice	— Participants in global research have clear, direct benefit — Protection of financially burdened subjects — Protection of subjects with acute or refractory illness

IBD, inflammatory bowel disease.