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. Author manuscript; available in PMC: 2014 May 3.
Published in final edited form as: Chromosome Res. 2013 May;21(3):255–269. doi: 10.1007/s10577-013-9356-x

Figure 2. Replication-dependent histone deposition model.

Figure 2

(A) Cell cycle information: the first S phase after genetic switch is discussed here. (B) H3-H4 tetramers are retained and loaded in a chromatid-specific manner at the replication fork. PcG binds specifically to old histone H3 that carries the H3K27me3 mark. PcG-PcG dimerization could bridge two H3-H4 tetramers to ensure their incorporation into the same sister chromatid. For simplicity, only one H3K27me3-Pc-Pc- H3K27me3 is shown here.