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Bone morphology: ESEM analysis at 1600 × magnification shows reduced bone mass in bone derived from 21 days ovariectomized mice as compared with that from naïve mice (A, B). Chronic treatment with palvanil reduced the spongy bone loss (C). Bone from Trpv1−/− mice-showed a high bone density and the bone loss after ovariectomy was not observed (D, E).
