Fig. 4.

Comparisons of reduced model simulations for the wild type and putative FPS1 mutant with the experimental data (Klipp et al. 2005). The osmotic shock was applied at t = 0 min by increasing the salt concentration from 0 to 0.5 M. The solid and dashed lines represent the insilico wild type and the mutant, respectively. Symbols open squares and open circles represent the experimental data for wild type and the putative FPS1 mutant, respectively. a Profiles of Hog1PP deviation (i.e. deviation from pre-shock level of wild type), normalised by the maximum deviation obtained in wild type. b The profiles of enzyme levels (deviation from pre-shock level of wild type), normalised by a fixed enzyme level. c Normalised error in turgor pressure as defined in Eq. 1. d Intracellular glycerol accumulation, normalised by pre-shock level in wild type