Table 1.
List of the genes analyzed in the study
| No. | Gene symbol | Gene Ida | Gene product official name (aliases) | Gene product functions | References |
|---|---|---|---|---|---|
| 1. | AGFG1/HRB | 5175 | Arf-GAP domain and FG repeats containing protein 1 | Probably mediates nucleocytoplasmic transport | [6, 7] |
| 2. | STC1 | 11373 | Stanniocalcin 1 | Probably regulates calcium/phosphate transport and metabolism | [6, 8] |
| 3. | SLC2A1 | 11005 | Solute carrier family member 2 (facilitated glucose transporter), member 1 | A major glucose transporter in the mammalian blood–brain barrier | [6, 8, 9] |
| 4. | CHKA | 1937 | Choline kinase alpha | Catalyzes the first step in phosphatidylcholine biosynthesis and contributes to phosphatidylethanolamine biosynthesis | [10] |
| 5. | CXCL1 | 4602 | Chemokine (C-X-C motif) ligand1 (melanoma growth stimulating activity, alpha) | Recruits neutrophil polymorphonuclear leukocytes at sites of inflammation; stimulates angiogenesis | [11, 12] |
| 6. | CXCL2 | 4603 | Chemokine (C-X-C motif) ligand 2 (melanoma growth stimulating activity, beta) | Recruits neutrophil polymorphonuclear leukocytes at sites of inflammation; stimulates angiogenesis | [11] |
| 7. | CXCL3 | 4604 | Chemokine (C-X-C motif) ligand 3 (melanoma growth stimulating activity, gamma) | Recruits neutrophil polymorphonuclear leukocytes at sites of inflammation; stimulates angiogenesis | [11, 12] |
| 8. | CXCL5 | 10642 | Chemokine (C-X-C motif) ligand5(epithelial-derived neutrophil activating protein 78 (ENA-78)) | Involved in neutrophil activation; stimulates angiogenesis | [11] |
| 9. | CXCL6 | 10643 | Chemokine (C-X-C motif) ligand 6 (granulocyte hemotactic peptide-2 (GCP-2)) | Is a chemoattractant for neutrophil granulocytes; stimulates tumor cell growth | [11] |
| 10. | CXCR2 | 6027 | Chemokine (C-X-C motif) receptor 2 (interleukin-8 receptor, beta) | Membrane receptor that binds chemokines CXCL6 and CXCL8 with high affinity | [11] |
| 11. | CXCR3 | 4540 | Chemokine (C-X-C motif) receptor 3 | Membrane receptor that binds chemokines CXCL9, CXCL10, and CXCL11 | [11] |
| 12. | CXCR4 | 2561 | Chemokine (C-X-C motif) receptor 4 | Membrane receptor specific for chemokine CXCL12/SDF-1. Important in the metastatic behavior of solid tumors | [11, 13, 14] |
| 13. | CXCL9 | 7098 | Chemokine (C-X-C motif) ligand 9 (monokine induced by gamma interferon (MIG)) | Is a Th1-cell attracting chemokine; blocks angiogenesis | [11, 12] |
| 14. | CXCL10 | 10637 | Chemokine (C-X-C motif) ligand 10 (10 kDa interferon-gamma-induced protein (IP-10)) | Is chemotactic for monocytes and T\ lymphocytes, has pleiotropic effects on these cells, and blocks angiogenesis | [11] |
| 15. | CXCL11 | 10638 | Chemokine (C-X-C motif) ligand 11 (0Interferon-inducible T cell alpha chemoattractant (I-TAC)) | Is a chemoattractant to interleukin-activated T cells; blocks angiogenesis | [11] |
| 16. | CXCL12 | 10672 | Chemokine (C-X-C motif) ligand 12 (Stromal cell-derived factor 1 (SDF-1)) | Is a chemoattractant to T lymphocytes and monocytes | [11, 14] |
| 17. | IL10 | 5962 | Interleukin-10 (cytokine synthesis inhibitory factor (CSIF)) | Inhibits the synthesis of a number of cytokines including interferon-gamma, IL-2, IL-3,TNF, and Gm-CSF produced by activated macrophages and by helper T cells | [15, 16] |
| 18. | IL6 | 6018 | Interleukin-6 (interferon, beta 2(IFNB2)) | A cytokine that functions in inflammation and the maturation of B cells and is a potent inducer of the acute phase response | [15] |
| 19. | IL8 | 6025 | Interleukin-8 (Chemokine (C-X-C motif) ligand 8(CXCL8)) | One of the major mediators of the inflammatory response; stimulates angiogenesis | [12, 15] |
| 20. | TNF | 11892 | Tumor necrosis factor (TNF superfamily, member 2) | A multifunctional pro-inflammatory cytokine involved in the regulation of a wide spectrum of cellular processes, including proliferation, differentiation, and apoptosis | [15] |
| 21. | ITGA5 | 6141 | Integrin, alpha 5 (Fibronectin receptor, alpha polypeptide) | A member of integrin family of membrane receptors involved in cell adhesion | [17] |
| 22. | ITGB3 | 6156 | Integrin, beta 3 (platelet glycoprotein IIIa, AntigenCD61) | A member of integrin family of membrane receptors involved in cell adhesion | [17] |
| 23. | ITGB1 | 6153 | Integrin, beta 1 (Fibronectin receptor) | A member of integrin family of membrane receptors involved in cell adhesion | [17] |
aAccording to HUGO Gene Nomenclature Committee (HGNC)