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. 2014 Apr 16;2014:962962. doi: 10.1155/2014/962962

Table 1.

List of genes that are reported to be transcriptionally and translationally regulated by FGF-1 in humans and other mammals.

  Gene symbol Up-/down regulation mRNA/Protein Experiment Organism Tissue/cell line/type PubMed ID Transcriptional regulator Regulator Gene ID PubMed ID
1 APOE Up mRNA and protein RT-PCR, Western blot Rat Astrocytes 18216067, 19229075, 17548887, 15627653      
2 BAMBI Down mRNA and protein RT-PCR, Western blot Human Preadipocytes 22187378      
3 CCND1 Up mRNA and protein Gene chip array, Western blot Human, rat MG63 osteoblastic cells, Rat Wister bladder tumor cells (NBT-II) 15572039, 18189245      
4 CDK5R1 Up mRNA and protein Q-PCR, Western blot Rat PC12 cells 19249349      
5 CDKN1A Up mRNA and protein RT-PCR, Western blot Human, mouse, rat Chondrocytes, REtsAF cells 16091747, 16153144, 11779141, 10364154 STAT1 6772 11779141, 10364154
6 CEBPA Up mRNA and protein RT-PCR, Western blot Human, mouse Preadipocytes, 3T3-L1 cells 17068114      
7 CEBPB Up mRNA and protein RT-PCR, Western blot Human, mouse Preadipocytes, 3T3-L1 cells 17068114      
8 COX2 Up mRNA and protein Northern blot, ELISA Human, rabbit Cardiac muscle microvessel endothelial cells 8790580, 2107185      
9 EGR1 Up mRNA and protein Q-PCR, Western blot Mouse, rat PC12 cells, Hippocampal neuronal cell line HT22, human periodontal ligament cells 19249349, 20649566, 18179472, 24396070 STAT3, SP1 6774, 6667 24396070
10 FOS Up mRNA and protein RT-PCR, northern blot (mouse and rat), Immunohistochemistry, Western blot Mouse, rat, human 3T3 cells, Adipocytes, ENU1564 cell, Astrocytes of periventricular zone of third ventricle, SUM-52PE cells 16309174, 2507555, 18041768, 11172932, 20388777      
11 JUN Up mRNA and protein RT-PCR, Western blot Rat ENU1564 cells 18041768      
12 JUNB Up mRNA and protein Gene chip array (Rat), Western blot Rat, human Rat Wister bladder tumor cells (NBT-II), SUM-52PE cells 18189245, 20388777      
13 MDM2 Up mRNA and protein RT-PCR, Western blot Rat REtsAF cells 16091747    
14 MMP14 Up mRNA and protein Northern blot, Gene chip array, Western blot Human, rat Prostate cancer cell line, LNCaP, Rat Wister bladder tumor cells (NBT-II) 14673954, 18189245 STAT3 6774 14673954
15 MMP9 Up mRNA and protein RT-PCR, Gene chip array, Western blot Rat ENU1564 cells, Rat Wister bladder tumor cells (NBT-II) 18041768, 18189245 RELA, JUN, FOS 5970, 3725, 2353 18041768
16 MYC Up mRNA and protein Northern blot (Mouse), Western blot Mouse, human 3T3 cells, SUM-52PE cells 16309174, 20388777      
17 NOS2 Up mRNA and protein RT-PCR, Western blot Rat Astrocytes 16524372      
18 PLAU Up mRNA and protein RT-PCR, ELISA Human Fibroblasts 12008951      
19 PPARG Up mRNA and protein RT-PCR, Western blot Human, mouse Preadipocytes, 3T3-L1 cells 17068114, 22187378      
20 SLC2A4 Up mRNA and protein RT-PCR, Western blot Human, mouse Preadipocytes, 3T3-L1 cells 22187378, 17068114      
21 THY1 Up mRNA and protein Northern blot, Western blot Rat PC12 cell lines 11084019      
22 TNFRSF12A Up mRNA and protein RT-PCR, Immunoblot Rat Cardiomyocytes 19629561      
23 NGF Up mRNA and Protein RT-PCR, Enzyme Immuno assay Rat Hippocampal astrocytes, skin fibroblasts, Primary spinal cord astrocyte 1377078, 15773903      
24 VEGFA Up mRNA and protein Real time PCR, ELISA Human Primary human airway smooth muscle cells 22205500      
25 ACPL2 Down mRNA Microarray Mouse Osteoblast cells 18505824      
26 ARG1 Up mRNA Gene chip array, Q-PCR Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
27 ATP2A2 Up mRNA RNA gel blot Mouse NIH 3T3 cells 7506544      
28 AXIN2 Down mRNA Microarray Mouse Osteoblast cells 18505824      
29 BGLAP Up mRNA in situ hybridization Mouse Mouse calvaria cells (coronal sutures) 12674336      
30 CTSC Up mRNA Gene chip array Rat Rat wister bladder tumor cells (NBT-II) 18189245      
31 DKK3 Down mRNA Microarray Mouse Osteoblast cells 18505824      
32 DLL1 Down mRNA Northern blot Mouse Neuroepithelial precursor (E10) 11466430      
33 DUSP1 Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245    
34 DYNC2LI1 Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
35 EDNRA Up mRNA Northern blot Rat Arterial smooth muscle cells 12851419      
36 EFNB1 Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
37 ELF4 Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
38 FASN Up mRNA RNA gel blot Mouse NIH 3T3 cells 7506544      
39 FGF1 Up mRNA RT-PCR Rat Pheochromocytoma cells 8576258      
40 FGF7 Up mRNA RT-PCR Mouse Embryonic lung mesenchymal cells 10446271      
41 FN1 Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
42 FZD1 Down mRNA Microarray Mouse Osteoblast cells 18505824      
43 FZD2 Down mRNA Microarray Mouse Osteoblast cells 18505824      
44 FZD7 Down mRNA Microarray Mouse Osteoblast cells 18505824      
45 FZD8 Down mRNA Microarray Mouse Osteoblast cells 18505824      
46 F3 Down mRNA Northern blot Human Human umbilical vein endothelial cells 9157959      
47 GADD45A Down mRNA Microarray Mouse Osteoblast cells 18505824      
48 HBEGF Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
49 HMGA2 Down mRNA Northern blot Rat 3T3-L1 cells 10490844      
50 IBSP Up mRNA in situ hybridization Mouse Mouse calvaria cells (coronal sutures) 12674336      
51 IGF1 Down mRNA RT-PCR Human Fibroblasts 12008951      
52 IGF2 Down mRNA RT-PCR Human Fibroblasts 12008951      
53 IGF1R Down mRNA RT-PCR Human Fibroblasts 12008951      
54 IGF2R Down mRNA RT-PCR Human Fibroblasts 12008951      
55 IGFBP4 Down mRNA RT-PCR Human Fibroblasts 12008951      
56 IL4 Up mRNA Q-PCR Rat Transected spinal cord tissue 21411654      
57 IRS1 Down mRNA Microarray Mouse Osteoblast cells 18505824      
58 LAMA3 Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
59 LRRC17 Down mRNA Microarray Mouse Osteoblast cells 18505824      
60 MITF Up mRNA Microarray Mouse Osteoblast cells 18505824      
61 MMP13 Up mRNA Gene chip array, Q-PCR Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
62 MMP3 Up mRNA Northern blot Rat PC12 cell lines 11084019      
63 MSH6 Up mRNA RNA gel blot Mouse NIH 3T3 cells 8870641    
64 MSX2 Up mRNA in situ hybridization Mouse Mouse calvaria cells 12674336      
65 NID2 Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
66 NOTCH1 Up mRNA Northern blot, Gene chip array, Q-PCR Mouse, rat Neuroepithelial precursor (E10), bladder tumor cells (NBT-II) 11466430, 18189245      
67 NR1H3 Up mRNA RT-PCR Rat Astrocytes 19229075      
68 ODC1 Up mRNA Northern blot Mouse NIH 3T3 cells 9223379      
69 PDGFA Up mRNA RNA gel blot Human HUVE cells 1689299      
70 PFKL Up mRNA RNA gel blot Mouse NIH 3T3 cells 7506544      
71 PLAT Up mRNA RT-PCR Human Fibroblasts 12008951      
72 PLAUR Up mRNA RT-PCR Human Fibroblasts 12008951      
73 PLF Up mRNA Northern blot Mouse NIH 3T3 cells 9223379      
74 PMEPA1 Down mRNA Microarray Mouse Osteoblast cells 18505824      
75 PNRC1 Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
76 POSTN Up mRNA Northern blot Rat Pulmonary arterial smooth muscle cells 15121739      
77 PPIA Up mRNA Northern blot Rat PC12 cell lines 11084019      
78 PRICKLE1 Down mRNA Microarray Mouse Osteoblast cells 18505824      
79 PRPH Up mRNA Northern blot Rat PC12 cell lines 11084019      
80 PTPRE Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
81 RUNX2 Up mRNA in situ hybridization Mouse Mouse calvaria cells (coronal sutures) 12674336      
82 SCGB1A1 Up mRNA RT-PCR Mouse Mouse lung epithelium 12242715      
83 SDC1 Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
84 SERPINB1 Down mRNA Microarray Mouse Osteoblast cells 18505824      
85 SERPINB2 Up mRNA RT-PCR Human Fibroblasts 12008951      
86 SERPINE1 Up mRNA RT-PCR Human Fibroblasts 12008951      
87 SFRP1 Down mRNA Microarray Mouse Osteoblast cells 18505824      
88 SFTPC Up mRNA RT-PCR Mouse Mouse lung epithelium, Embryonic stem cell (mESC) line E14-Tg2a 12242715, 20497026      
89 SOCS1 Up mRNA Northern blot Rat Mouse lens epithelium 14985304      
90 SOCS3 Up mRNA Northern blot Rat Mouse lens epithelium 14985304      
91 SOX2 Up mRNA Microarray Mouse Osteoblast cells 18505824    
92 SPP1 Up mRNA Quantitative northern blot Rat Pulmonary arterial smooth muscle cells 15121739      
93 SPRY1 Up mRNA RNA gel blot Mouse MC3T3-E1 osteoblasts 16604287      
94 SPRY2 Up mRNA RNA gel blot Mouse MC3T3-E1 osteoblasts 16604287      
95 SPRY4 Up mRNA RNA gel blot Mouse MC3T3-E1 osteoblasts 16604287      
96 S1PR3 Up mRNA Northern blot Human Human umbilical vein endothelial cells 9315732      
97 TCF3 Down mRNA Microarray Mouse Osteoblast cells 18505824      
98 TCF4 Down mRNA RT-PCR Human Preadipocytes 22187378      
99 TGFA Up mRNA Northern blot Mouse Cultured keratinocytes 7535082      
100 TGFB2 Down mRNA Microarray Mouse Osteoblast cells 18505824      
101 TGFBR3 Down mRNA Microarray Mouse Osteoblast cells 18505824      
102 THBS1 Down mRNA Microarray Mouse Osteoblast cells 18505824      
103 THBS1 Up mRNA Northern blot Mouse NIH 3T3 cells 9223379      
104 TIMP1 Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
105 TIMP3 Down mRNA Microarray Mouse Osteoblast cells 18505824      
106 VIM Up mRNA Gene chip array Rat Rat Wister bladder tumor cells (NBT-II) 18189245      
107 ADIPOQ Up Protein Radioimmunoassay Human Preadipocytes 17068114      
108 CCNE1 Up Protein Western blot Human MG63 osteoblastic cells 15572039      
109 CTNNB1 Down Protein Western blot Human Simpson Golabi Behmel syndrome (SGBS), Preadipocytes 22187378      
110 HMOX1 Up Protein Western blot Human Spinal cord astrocytes 16524372      
111 MMP7 Up Protein ELISA Human LNCaP cells 11922392 STAT3 6774 11922392
112 PKMYT1 Up Protein Immunoblot Rat Chondrosarcoma cells 21051949      
113 PLIN1 Up Protein Western blot Human, mouse Preadipocytes, 3T3-L1 cells 17068114      
114 PTGIS Down Protein ELISA Human Endothelial cells 2107185      
115 PTGS2 Down Protein ELISA Human Endothelial cells 2107185      
116 RELA Up Protein Western blot Rat ENU1564 cells 18041768      
117 RHOA Up Protein Immunoblot Rat Cardiomyocytes 19629561      
118 SOX9 Up Protein Western blot Mouse Costal chondrocytes 10655493      
119 WEE1 Up Protein Immunoblot Rat Chondrosarcoma cells 21051949      
120 CDH2 Up Protein Western blot Rat PC12 cells 24396070 STAT3, SP1 6774, 6667 24396070
121 GAP43 Up Protein Western blot Rat PC12 cells 24396070 STAT3 6774 24396070