Table 2.
Functions of FGF-1 identified in diverse cell/tissue types of human and other mammalian origins.
| Function | PubMed ID | Cell type/tissue | Organism |
|---|---|---|---|
| Adipogenesis | 22187378, 17068114 | Preadipocytes | Human |
| Apoptosis | 20657013 | Hepatoma cells, HEK293 cells | Human |
| 15773903 | Motor neuron | Rat | |
| 9681989 | Peroxynitrite-induced apoptosis in PC12 cells | Rat | |
| Cell cycle arrest | 16153144 | cells | Human |
| Cell migration | 9108375 | Skin fibroblasts | Human |
| 11019781 | Fibroblasts | Mouse | |
| Cell proliferation | 9182757 | Embryo fibroblasts | Rat |
| 2441696 | Arterial smooth muscle cells | Human | |
| 14966081 | AT2 alveolar cells | Human | |
| 15094393 | Human long-bone growth plate chondrocytes | Human | |
| 1699952 | Umbilical vein endothelial ceils | Human | |
| 15767480 | Y79 cells | Human | |
| 2303528 | Epidermal keratinocytes (BALB-MK1) | Mouse | |
| 2303528 | Keratinocytes (BALB/MK-1) | Mouse | |
| 2383402 | Leydig cells (TM3) | Mouse | |
| 1379845 | Megakaryocyte progenitor cells | Mouse | |
| 1379845 | Megakaryocytes | Mouse | |
| 14985304 | Murine lens epithelial cell lines CRLE2, 1AMLE6, TN4-1 and NKR11 | Mouse | |
| 15574884 | NIH-3T3 cells | Mouse | |
| 3272188 | Adrenal chromaffin cells | Rat | |
| 2566605 | Astroblasts | Rat | |
| 1377078 | Hippocampal astrocytes | Rat | |
| 2153969 | Rat bladder carcinoma cell line (NBT-II) | Rat | |
| 8622701 | PC12 cells | Rat | |
| 8732667 | Prostate cancer cells | Rat | |
| 1638984 | Retinal cells | Rat | |
| 1377078 | Skin fibroblasts | Rat | |
| 12907464 | Aortic smooth muscle cells | Human, rat | |
| 1638984 | Retinal cells | Rats | |
| 22108586 | Periodontal fibroblasts | Rat | |
| 3272188 | Adrenal chromaffin cells | Rat | |
| 22108586 | Periodontal ligament fibroblasts | Rat | |
| 20388777 | SUM-52PE cells | Human | |
| Cell rounding, growth inhibition | 11779141 | ATDC5 cells, chondroprogenitor cell lines | Mouse |
| Cholesterol biosynthesis | 19713443 | Mouse fibroblasts and rat astrocytes | Mouse, rat |
| 19229075 | Astrocytes | Rat | |
| 18216067 | Astrocytes | Rat | |
| 17548887 | Astrocytes | Rat | |
| Differentiation | 20497026 | Embryonic stem cell (mESC) line E14-Tg2a | Mouse |
| Epithelial-mesenchymal transition | 2153969 | NBT-II cells (Rat bladder carcinoma cell line) | Rat |
| 7593195 | NBT-II | Rat | |
| 2153969 | NBT-II | Rat | |
| Fiber cell differentiation | 7539358 | Lens epithelial cells | Mouse |
| G0/G1 arrest | 21051949 | Chondrosarcoma cells | Rat |
| G2 arrest | 21051949 | Chondrosarcoma cells | Rat |
| G2/M transition | 20044603 | Breast cancer cells | Human |
| Growth arrest | 14593093 | Rat chondrosarcoma (RCS) cells | Rat |
| Inhibition of apoptosis | 16524372 | Astrocytes | Rat |
| 17473910, 16091747 | PC12 and RetsAF cells | Rat | |
| Inhibition of cell growth | 17363592 | TAKA-1 cells | Hamster |
| Inhibition of neurogenesis | 11466430 | NEP cells | Mouse |
| Inhibition of proliferation | 10364154 | Chondrosarcoma cells (RCS) | Rat |
| Membrane ruffling | 7534069 | Human ductal breast epithelial tumor cell line (T47D) | Human |
| Neurite outgrowth | 20175207 | TREX 293 cells | Human |
| 3272188 | Adrenal chromaffin cells | Rat | |
| 8764646 | PC12 cells | Rat | |
| 19249349 | PC12 cells | Rat | |
| 3316527, 8576258 | PC12 cells | Rat | |
| 12127979, 9182757, 2157719 | PC12 cells | Rat | |
| Neuronal differentiation | 16716298 | Primary astrocyte from human fetal brain | Human |
| 7514169, 8622701, 2157719 | PC12 cells | Rat | |
| Osteoblast proliferation | 18041768 | ENU1564 cells | Rat |
| Osteoblast differentiation | 18505824 | Osteoblasts | Mouse |
| Osteogenic differentiation | 12674336 | Sutural mesenchyme in mouse calvaria | Mouse |
| Protection from apoptosis | 19765618, 8576258 | PC12 cells | Rat |
| Repression of myogenic differentiation | 1379245 | Skeletal muscle myoblasts (MM14) | Mouse |
| Retinal cell proliferation | 15978261 | Retinal cells | Mouse |
| Skeletal muscle development | 8601591 | Skeletal muscle myoblasts (MM14) | Mouse |
| Synaptic plasticity | 20649566 | Hippocampal neuronal cell line HT22 | Mouse |
| Tumorigenesis | 20889570 | JMSU1 urothelial carcinoma cell lines | Human |
| 9038374 | NBD-II | Rat | |
| Vascular remodeling | 15121739 | Pulmonary arterial smooth muscle cells (PASMCs) | Rat |
| 22205500 | ASM (Airway Smooth Muscle cells) | Human | |
| Regeneration | 3353388 | Retinal ganglion cells | Rat |
| Astrocyte activation | 15773903 | Primary spinal cord astrocyte | Rat |
| Neurogenesis | 20429889 | Embryonic stem cells | Mouse |
| Wound healing | 9036931 | Mouse | |
| Cord Formation | 16631103 | Rat | |
| Decrease in food intake | 7692459 | Rat | |
| Facilitation of memory | 7692459 | Rat | |
| Increase in sleep duration | 8985960 | Rabbit | |
| Maintenance of the integrity of the organ of corti, initiation of protective recovery and repair processes following damaging auditory stimuli | 7568115 | Rat | |
| Arteriole dilation | 8853345 | Rat | |
| Feeding suppressor function | 11172932 | Rat | |
| Hair-cell innervation during the terminal development of the sensory epithelium | 12792312 | Rat | |
| Lens regeneration | 3792708 | Bovine | |
| Lung morphogenesis and differentiation | 12242715 | Rat | |
| Metastasis | 1707175 | Rat | |
| Muscle regeneration | 1384586 | Mouse | |
| Myocardial remodeling | 19629561 | Rat | |
| Neuroprotection | 12095987 | Rat | |
| Prevention of premature angiogenesis and inflammatory responses | 17643421 | Mouse | |
| Protection against hypoxic-ischemic injury | 16635575 | Rat | |
| Spinal cord injury repair | 21411654 | Rat | |
| Cardioprotection | 15337227, 12176126 | Mouse |